Holland Laboratory

Dr Linda Z Holland
Research Biologist

Dr Nicholas Holland
Professor of Marine Biology

Scripps Institution of Oceanography
University of California San Diego
La Jolla, CA 92093-0202 USA
Phone: 858 534 5607 Fax: 858 534 7313
Email: lzholland@ucsd.edu | nholland@ucsd.edu

Street Address: 8750 Biological Grade, 4400 Hubbs Hall, La Jolla, CA 92037 USA

Web address: http://hollandlab.ucsd.edu/intro.htm

Amphioxus is generally considered the closest living relative of the vertebrates. In spite of half a billion years of parallel evolution, amphioxus is a useful stand-in for the proximate invertebrate ancestor of the vertebrates. Its body plan and genomic organization are both vertebrate-like, but much simpler. In 1988-1989 we developed methods for inducing spawning of amphioxus and rearing embryos through metamorphosis, which set the groundwork for developmental genetic studies starting in 1992. This research takes advantage of the remarkable conservation of developmental genes across a wide range of animal phyla--in sequence, expression and in function.

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